The Science Behind ThyroLove

Form used in ThyroLove:

Myo-inositol (600mg)

Why it’s in ThyroLove: Myo-inositol supports thyroid hormone synthesis, TSH signaling, blood sugar balance, and may help reduce thyroid antibodies in Hashimoto’s. This is one of the most well-researched nutrients for improving thyroid function naturally.

The Science:

• Supports thyroid hormone production: Myo-inositol helps produce hydrogen peroxide (H2O2), which is required to synthesize thyroid hormones.

• TSH signaling: Plays a role in the second messenger system where TSH binds in the thyroid and signals hormone production. When TSH levels rise, thyroid cells accumulate more inositol.

• Deficiency and dysfunction: Low levels or poor signaling may increase risk for autoimmune thyroid disease and hypothyroidism. Those with thyroid disease may have greater needs.

• Clinically shown to reduce antibodies and TSH: A trial of 186 patients with TSH 3.0–6.0 taking 600 mg myo-inositol + 83 mcg selenium showed reduced TSH, improved free T4, and decreased TPO and thyroglobulin antibodies (PMC8143049).
• Another 6-month study of 86 Hashimoto’s patients found significant TSH reduction (from 4.32 to 3.12), improved T3/T4, and reduced antibodies. Even one hyperthyroid patient normalized TSH—suggesting a balancing effect (PMC5331475).

• Nodule support: May help manage benign thyroid nodules.

• Structural component of cell and mitochondrial membranes and needed for energy

• Iodine synergy: Myo-inositol may increase iodine availability and support proper uptake.

Blood Sugar & Metabolic Health:

• Supports insulin signaling and improves insulin sensitivity.
• Helps glucose break down into ATP (energy), supporting mitochondrial function.
• May reduce gestational diabetes risk (PMC9930614).
• Supports ovarian and metabolic health, especially in PCOS and perimenopause (PMC10145676).
• Factors that increase the body’s need for inositol include: caffeine, advancing age, antibiotic use, sugar intake, refined carbohydrate intake, sodium deficiency, insulin resistance, type 1 diabetes, type 2 diabetes. 
• High blood sugar reduces inositol due to lower absorption, higher excretion, and impaired synthesis.
• Supplementing may improve glucose metabolism, which is key for Hashimoto’s-related weight loss (BMJ Open Heart).

While the Western diet typically provides around 1 gram of inositol daily, absorption can be compromised by factors like gut dysbiosis, medications, and caffeine. The body also makes its own inositol, up to 4 grams per day in the kidneys, but this process may be impaired in certain health conditions. Although inositol is present in foods like walnuts, Brazil nuts, beans, peas, cantaloupe, almonds, and citrus fruits, ancestral diets were naturally richer in it due to the consumption of organ meats, such as kidneys and brain, which are no longer common in modern meals. 

Because of this, many people, especially those with Hashimoto’s, may benefit from targeted inositol supplementation.

A quick note from me to you:

Because inositol is so powerful in supporting TSH and blood sugar, it’s possible that some may actually need less thyroid medication or blood sugar support (if you are on diabetes medication) over time. 

Everyone is different, of course, but I’ve seen this happen enough that I always recommend keeping an eye on things. For this reason, please monitor your thyroid labs and check your blood sugar regularly while taking ThyroLove, especially if you’re already on medication and work closely with your provider to assess those results to monitor your medication needs.

When checking thyroid labs, I always recommend a full thyroid panel so that you can really assess how things are working. A full Thyroid Panel includes: TSH, Total T4, Total T3, Free T4, Free T3, Reverse T3, T3 Uptake and Thyroid Antibodies (Thyroid Peroxidase Antibodies-TPO and Thyroglobulin Antibodies-TG)

Forms used in ThyroLove:

• Vitamin B12 as adenosylcobalamin and methylcobalamin (50 mcg total)
• Folate as L-5-methyltetrahydrofolate (1020 mcg DFE)
  

Why they’re in ThyroLove:
If you’ve ever taken a standard multivitamin and felt worse afterward, this might be why. Many people with Hashimoto’s have sluggish methylation or genetic variants like MTHFR that impair their ability to convert synthetic forms like folic acid and cyanocobalamin into the usable, active forms the body needs. That’s why ThyroLove contains only natural, methylated, bioidentical nutrients and NO synthetic folic acid, no synthetic B12.

We also chose a thoughtful blend of both methylcobalamin (for direct methylation support) and adenosylcobalamin (for energy production that doesn’t involve methylation). This balance is especially important for those who are sensitive to too much methylation. I know that there is so much talk about needing more methylation but believe it or not, there is such a thing of too much of a good thing and too much methylation is a real thing as well, something I’ve seen often in my practice, especially in Hashimoto’s and have this myself as well. That is why the combination of the methylcobalamin and adenosylcobalamin, this way you get the benefits of active B vitamins without the overload. It’s a balance that respects your biology.

The Science:

• Vitamin B12 deficiency is common in Hashimoto’s, with studies showing rates as high as 46%. Low B12 is also correlated with higher TPO antibodies.
  Study: PMC9223845

• Methylcobalamin is the active methylated form of B12 used in the methylation cycle, which affects detox, hormone metabolism, and immune function.

• Adenosylcobalamin is an active form of vitamin B12 and supplementing with this form means it’s immediately available to cells. This form of vitamin B12 helps cells in the process of turning glucose/calories into energy Study: PMC5312744

• Folate vs. folic acid: Folic acid is a synthetic form that must be converted into usable folate—a process that’s often impaired in people with methylation SNPs like MTHFR. ThyroLove includes L-5-methyltetrahydrofolate (5-MTHF), the same form found in leafy greens and what your body already uses.
  Study: PubMed 20608755
  Study: PMC8961567

• Supplementing with the wrong forms of folate and B12 (like folic acid or cyanocobalamin) can lead to unmetabolized synthetic nutrients building up in the body, which may interfere with detox, fertility, and overall methylation balance.

And of course, ThyroLove includes the rest of the B family too, each in its most gentle, effective form. You’ll find B6 as P5P (the active form), which supports mood and hormone balance, and biotin, which helps nourish hair and skin which is something many of us with Hashimoto’s need a little extra love around. The full B-complex is blended in just the right balance to support energy, metabolism, and thyroid health without overdoing it.

Form used in ThyroLove:
Ferrochel iron (ferrous bisglycinate chelate) 6 mg

Why it’s in ThyroLove:
Iron is essential for thyroid hormone production and oxygen delivery throughout the body, but many people with Hashimoto’s don’t absorb enough from food, especially if stomach acid is low, which is really common with hypothyroidism. 

The form we chose is chelated for optimal absorption and binds iron to glycine, making it much gentler on digestion and less likely to cause constipation than typical iron supplements. We also used just the right amount, enough to support your thyroid and energy levels without overloading your system. Too much iron can be inflammatory or poorly tolerated, so this form and dose strike that sweet spot for gentle, effective support.

The Science:

• Ferrochel is a patented, chelated form of iron that binds to the amino acid glycine, enhancing absorption and reducing digestive side effects.
  Study: PubMed 11688078

• Iron is critical for thyroid hormone synthesis. Without enough, your thyroid may struggle to convert T4 into active T3, even if labs appear “normal.”

• Absorption of iron is often reduced in Hashimoto’s due to low stomach acid, gut inflammation, or autoimmune activity.

• Iron deficiency is common in women, especially with heavy periods, and can sometimes be missed if only ferritin is measured, since inflammation can falsely elevate that marker.

Quick note from me to you:

I can’t tell you how many people I’ve worked with who finally started to feel more energetic and balanced once we got their iron to the right place. But iron supplements can be rough and the constipation, nausea, and stomach issues are no joke. That’s why I use Ferrochel in ThyroLove. It’s the most well-tolerated form I’ve seen, and I included a gentle dose to give your body what it needs without overdoing it.

Form used in ThyroLove:
Zinc bisglycinate chelate (30 mg)

Why it’s in ThyroLove:
Zinc is one of the most important minerals for thyroid and immune health and unfortunately, most multivitamins simply don’t include enough of it. The form we use, zinc bisglycinate chelate, is bound to the amino acid glycine, which makes it highly absorbable and gentle on the stomach. We included a therapeutic dose of 30 mg which is much more than the typical 8 mg found in basic supplements, because that’s what it takes to make a real impact in people with Hashimoto’s. It also supports gut healing, skin health, and immune balance, all of which are often compromised in thyroid conditions.

The Science:

• Low zinc levels are commonly seen in hypothyroidism and autoimmune thyroid conditions, and deficiency may contribute to symptoms like fatigue, hair loss, and poor wound healing.
  Study: PMC10385100

• Zinc plays a key role in the conversion of T4 to T3, the active thyroid hormone. Without enough zinc, this conversion can slow down, leading to symptoms of low thyroid even when T4 levels appear normal.

• Zinc supports immune regulation, and when zinc levels are restored, immune function improves and that can also positively affect thyroid health.

• The bisglycinate chelate form is shown to have better absorption than other types of zinc, especially in people with digestive issues or compromised gut function.
  Study: PubMed 24259556

Form used in ThyroLove:
Selenium glycinate chelate (200 mcg)

Why it’s in ThyroLove:
Selenium is one of the most well-researched nutrients for Hashimoto’s, and for good reason. It helps protect the thyroid from oxidative stress and supports the conversion of T4 into active T3. We use selenium glycinate, a chelated form that’s gentle, bioavailable, and highly absorbable. And we included it at 200 mcg, the optimal dosage shown in studies to support thyroid antibodies and immune balance. It’s a true must-have for thyroid function and immune balance and support.

The Science:

• Selenium plays a key role in thyroid hormone metabolism, antioxidant protection, and immune function, all essential areas in Hashimoto’s.

• A 2024 systematic review and meta-analysis found that selenium supplementation without thyroid hormone replacement therapy helped reduce TSH levels and TPO antibodies in patients with Hashimoto’s.
  Study: PMC10951571

• Selenium is a cofactor for enzymes like glutathione peroxidase, which help reduce inflammation and oxidative stress in the thyroid, therefore protecting it from further immune attack.

• Selenium deficiency is more common in autoimmune thyroid disease, especially in regions with low soil selenium levels or in people with poor absorption due to gut issues.

• The glycinate form is chelated for better absorption and is gentle on digestion, making it a great choice for anyone especially those who are more sensitive to supplements.

Form used in ThyroLove:
Mixed tocopherols (143 mg)

Why it’s in ThyroLove:
Most vitamin E supplements only include one form, alpha-tocopherol, but ThyroLove provides a broader spectrum of support with mixed tocopherols, including alpha-, beta-, delta-, and gamma-tocopherol. These are the four main tocopherols found in nature, and they work synergistically to provide antioxidant protection and support immune function. We chose this natural, full-spectrum blend to better reflect what your body actually needs, especially for those with Hashimoto’s, where antioxidant support plays a key role in protecting thyroid tissue and promoting balance.

The Science:

• Vitamin E is a powerful antioxidant, helping to protect the thyroid gland from oxidative stress and cellular damage.

• Higher intake of vitamin E has been associated with lower rates of subclinical hypothyroidism, suggesting it may play a protective role in thyroid function.
  Study: PubMed 38534308

• Mixed tocopherols more closely resemble the vitamin E profile found in real, whole foods, unlike isolated alpha-tocopherol, which may actually deplete other forms of vitamin E over time and can do more harm than good. We only wanted what mimicked nature here.

• Antioxidant support is especially important in autoimmune conditions like Hashimoto’s, where chronic inflammation can contribute to further thyroid damage.

Form used in ThyroLove:
Acerola cherry extract (250 mg)

Why it’s in ThyroLove:
Did you know that most vitamin C supplements are derived from corn? And corn can be a trigger and allergen with Hashimoto’s.  Instead of using synthetic, corn-derived ascorbic acid that most everyone else uses, we chose acerola cherry, a whole food source of vitamin C. It’s rich in naturally occurring antioxidants and bioflavonoids, and it’s easier on digestion for many people and its completely corn free. Vitamin C supports thyroid hormone levels, immune balance, and collagen production, which is why it’s so helpful for things like skin health and wound healing too.

The Science:

• Vitamin C levels tend to be lower in people with autoimmune thyroid disease, in part due to chronic inflammation and oxidative stress.
  Study: PMC10335618

• It plays a role in maintaining Total T4 and Total T3 levels. Research shows a non-linear relationship, meaning too little may negatively impact thyroid hormone circulation.
  Study: PMC11578698

• As a key antioxidant, vitamin C supports the immune system without overstimulating it (overstimulation is not good for Hashimoto’s or any autoimmune disease), reduces oxidative stress in thyroid tissue, and helps support adrenal health which is another huge player in Hashimoto’s.

• Whole food forms of vitamin C, like acerola cherry, are naturally rich in cofactors and plant compounds that enhance bioavailability and absorption.

Form used in ThyroLove:
Cholecalciferol (Vitamin D3) – 2000 IU

Why it’s in ThyroLove:

Vitamin D is often thought of for bone health, but it’s actually one of the most important immune regulators, especially when it comes to autoimmunity. I like to think of the immune system like a seesaw which is constantly swinging up and down in Hashimoto’s, either overreacting or underperforming. Vitamin D acts like the center of the seesaw, and when it’s strong and steady, it helps stabilize the swings. Imagine the middle part of the seesaw being wide and grounded—that’s what vitamin D does for immune balance. We use cholecalciferol (vitamin D3), the natural form your body makes from sunlight, at a dose of 2000 IU which is enough to support healthy levels without being excessive.

The Science:

• Vitamin D deficiency is very common in people with Hashimoto’s, especially in colder climates, indoor lifestyles, or those using sunscreen regularly.

• Vitamin D supports immune balance, and supplementation has been shown to reduce thyroid antibodies (TPO and TG), lower TSH, and increase free T4 and free T3.
  Study: PMC10754614

• A 2023 review concluded: “Current evidence supports the potential role of vitamin D in the prevention and management of Hashimoto’s thyroiditis.”
  Study: PMC10385100

• Many people still don’t get enough from diet and lifestyle alone, and the RDA (600 IU) is often way way too low to correct deficiency, especially in those that live in the northern hemisphere and have autoimmune conditions.

A quick note from me to you:

Whenever you take vitamin D, it’s so important that it’s paired with vitamin K2 in the right form. ThyroLove includes vitamin K2 as MK-7, which is the most bioavailable and longest-lasting form in the body. Here’s why that matters: vitamin D increases calcium absorption, which is great for your bones, but without enough K2, that calcium can end up in places it doesn’t belong, like arteries or soft tissue. Vitamin K2 acts like a traffic director, helping guide calcium out of your bloodstream and into your bones and teeth, where it belongs. I chose MK-7 specifically because it stays in your system longer than other forms, providing more consistent support for calcium regulation and overall heart and bone health. When D and K2 work together, it’s a beautiful thing and essential for safe, effective support, especially when you’re taking vitamin D consistently.

Form used in ThyroLove:
Beta-carotene (750 mcg)

Why it’s in ThyroLove:
Vitamin A plays a foundational role in thyroid function, immune balance, and even nutrient absorption, but not everyone needs or tolerates preformed vitamin A (retinol), which is why we use beta-carotene, a plant-based precursor that your body can convert as needed. This form gives your body flexibility so then it only converts what it needs, when it needs it. Plus, beta-carotene is a powerful antioxidant, helping to protect the thyroid and support overall immune resilience, which is especially important in Hashimoto’s.

The Science:

• Vitamin A is critical for thyroid hormone metabolism, including the conversion of T4 to T3 in the liver and the ability of cells to uptake thyroid hormone.
  Study: PMC9592814

• It also plays a structural role in maintaining thyroid gland health, and deficiency may impair the gland’s function and its ability to produce hormones.
  Study: PMC10250628

• Vitamin A supports regulatory T cells (Tregs), which are key in helping calm autoimmune activity and prevent the immune system from attacking healthy tissues.

• There’s also a connection between certain SNPs (genetic variations) in vitamin A metabolism and a higher risk for Hashimoto’s, meaning some people may have an even greater need for consistent, usable vitamin A.

Form used in ThyroLove:
Coenzyme Q10 (25 mg)

Why it’s in ThyroLove:
CoQ10 is one of those nutrients that doesn’t get talked about enough, but it’s absolutely essential when it comes to energy production, cellular repair, and mitochondrial health. Every single cell in your body uses CoQ10 to make energy, but people with Hashimoto’s and hypothyroidism often have lower levels which can be either from the condition itself, medications like statins, or just the added demand on the body from chronic inflammation. That’s why we included 25 mg of CoQ10 in ThyroLove to give your cells the extra support they need to function efficiently and feel more energized from the inside out.

The Science:

• CoQ10 is concentrated in the mitochondria, where it plays a direct role in producing ATP, the energy currency of the cell.

• People with thyroid disorders often have lower CoQ10 levels, which may contribute to fatigue, brain fog, and poor muscle recovery.

• CoQ10 also acts as an antioxidant, helping protect thyroid tissue and other cells from oxidative damage that can occur with chronic inflammation or autoimmune activity.

• Medications like statins can lower CoQ10 levels significantly, making supplementation especially important for anyone taking those medications.

• Even in people without deficiency, gentle CoQ10 support can enhance energy metabolism and overall mitochondrial function, which is especially helpful when your thyroid is underactive.

Form used in ThyroLove:
DiMagnesium Malate (150mg)

Why it’s in ThyroLove:

Magnesium is one of the most common nutrient deficiencies, and it is absolutely essential for those with Hashimoto’s. It supports energy production, relaxation, nervous system regulation, and thyroid hormone conversion. ThyroLove uses DiMagnesium Malate, a patented chelated form that binds magnesium to malic acid. This form is highly absorbable, gentle on digestion, and has the added benefit of supporting mitochondrial energy. We included 150 mg, which is a meaningful dose and much higher than what most multivitamins provide, which is why those others don’t often make a real difference. I chose this form and amount because it’s well tolerated and effective, without causing the digestive upset that many people experience with other types of magnesium.

The Science:

• Magnesium is involved in more than 300 enzymatic reactions, many of which are directly related to thyroid function, hormone balance, and adrenal support.

• It plays a role in converting T4 to T3, which is crucial for producing enough of the active thyroid hormone.

• Stress, chronic inflammation, caffeine, and common medications can all deplete magnesium stores, which may worsen symptoms like fatigue, irritability, constipation, or muscle cramps.

• The malate component helps support mitochondrial energy production, making this form of magnesium especially helpful for people experiencing low energy or chronic fatigue.

• People with Hashimoto’s often experience low stomach acid, which can make it harder to absorb minerals from food. Using a chelated form like DiMagnesium Malate helps bypass that issue and ensures better uptake.

Form used in ThyroLove:
Potassium iodide (25 mcg)

Why it’s in ThyroLove:
Iodine is one of the most misunderstood nutrients in thyroid health. While it’s essential for thyroid hormone production, too much iodine can actually be harmful for people with Hashimoto’s. In fact, high iodine intake has been shown to increase the risk of thyroid flare-ups, especially in those with autoimmune thyroid disease. This is why ThyroLove contains a very gentle dose, just 25 mcg. It is enough to prevent deficiency without pushing the thyroid into an over active and flared up state. Most multivitamins include 150 mcg and thyroid specific supplements often have even more, eeek!  And this is often too much for those with Hashimoto’s. I designed ThyroLove to give your body what it needs while being careful not to trigger a reaction.

The Science:

• Iodine is necessary for the thyroid to produce hormones. However, excess iodine can increase oxidative stress and worsen autoimmune activity in the thyroid gland.

• One study showed that even small increases in iodine intake, such as 250 mcg daily, could lead to thyroid dysfunction or flare-ups in Hashimoto’s. Study: PubMed 9703374

• Research also links high iodine content in drinking water to an increased risk of Hashimoto’s, especially in women.
  Study: PMC8585830

• The 25 mcg in ThyroLove is enough to support baseline thyroid needs without contributing to iodine excess, especially when combined with a balanced, thyroid-supportive diet.