Methylated B Vitamins

Forms used in ThyroLove

  • Vitamin B12 as adenosylcobalamin and methylcobalamin (50 mcg total)

  • Folate as L-5-methyltetrahydrofolate (1020 mcg DFE)

Why they’re in ThyroLove

If you’ve ever taken a standard multivitamin and felt worse afterward, this might be why. Many people with Hashimoto’s have sluggish methylation or genetic variants like MTHFR that impair their ability to convert synthetic forms like folic acid and cyanocobalamin into the usable, active forms the body needs. That’s why ThyroLove contains only natural, methylated, bioidentical nutrients and NO synthetic folic acid, no synthetic B12.

We also chose a thoughtful blend of both methylcobalamin (for direct methylation support) and adenosylcobalamin (for energy production that doesn’t involve methylation). This balance is especially important for those who are sensitive to too much methylation. I know that there is so much talk about needing more methylation but believe it or not, there is such a thing of too much of a good thing and too much methylation is a real thing as well, something I’ve seen often in my practice, especially in Hashimoto’s and have this myself as well. That is why the combination of the methylcobalamin and adenosylcobalamin, this way you get the benefits of active B vitamins without the overload. It’s a balance that respects your biology.

The Science

  • Vitamin B12 deficiency is common in Hashimoto’s, with studies showing rates as high as 46%. Low B12 is also correlated with higher TPO antibodies.
    Study: PMC9223845

  • Methylcobalamin is the active methylated form of B12 used in the methylation cycle, which affects detox, hormone metabolism, and immune function.

  • Adenosylcobalamin is an active form of vitamin B12 and supplementing with this form means it’s immediately available to cells. This form of vitamin B12 helps cells in the process of turning glucose/calories into energy Study: PMC5312744

  • Folate vs. folic acid: Folic acid is a synthetic form that must be converted into usable folate, a process that’s often impaired in people with methylation SNPs like MTHFR. ThyroLove includes L-5-methyltetrahydrofolate (5-MTHF), the same form found in leafy greens and what your body already uses.
    Study: PubMed 20608755
     Study: PMC8961567

  • Supplementing with the wrong forms of folate and B12 (like folic acid or cyanocobalamin) can lead to unmetabolized synthetic nutrients building up in the body, which may interfere with detox, fertility, and overall methylation balance.

And of course, ThyroLove includes the rest of the B family, too, each in its most gentle, effective form. You’ll find B6 as P5P (the active form), which supports mood and hormone balance, and biotin, which helps nourish hair and skin—something many of us with Hashimoto’s need a little extra love around. The full B-complex is blended in just the right balance to support energy, metabolism, and thyroid health without overdoing it.