Myo-Inositol (600 mg)

Form used in ThyroLove

Myo-inositol (not D-chiro-inositol)

Why it’s in ThyroLove

Myo-inositol supports thyroid hormone synthesis, TSH signaling, blood sugar balance, and may help reduce thyroid antibodies in Hashimoto’s. This is one of the most well-researched nutrients for improving thyroid function naturally.

The Science

  • Supports thyroid hormone production: Myo-inositol helps produce hydrogen peroxide (H2O2), which is required to synthesize thyroid hormones.

  • TSH signaling: Plays a role in the second messenger system where TSH binds in the thyroid and signals hormone production. When TSH levels rise, thyroid cells accumulate more inositol.

  • Deficiency and dysfunction: Low levels or poor signaling may increase risk for autoimmune thyroid disease and hypothyroidism. Those with thyroid disease may have greater needs.

  • Clinically shown to reduce antibodies and TSH:

    • A trial of 186 patients with TSH 3.0–6.0 taking 600 mg myo-inositol + 83 mcg selenium showed reduced TSH, improved free T4, and decreased TPO and thyroglobulin antibodies (PMC8143049).

    • Another 6-month study of 86 Hashimoto’s patients found significant TSH reduction (from 4.32 to 3.12), improved T3/T4, and reduced antibodies. Even one hyperthyroid patient normalized TSH, suggesting a balancing effect (PMC5331475).

  • Nodule support: May help manage benign thyroid nodules.

  • Structural component of cell and mitochondrial membranes and needed for energy

Blood Sugar & Metabolic Health

  • Supports insulin signaling and improves insulin sensitivity.

  • Helps glucose break down into ATP (energy), supporting mitochondrial function.

  • May reduce gestational diabetes risk (PMC9930614).

  • Supports ovarian and metabolic health, especially in PCOS and perimenopause (PMC10145676).

  • Factors that increase the body’s need for inositol include: caffeine, advancing age, antibiotic use, sugar intake, refined carbohydrate intake, sodium deficiency, insulin resistance, type 1 diabetes, type 2 diabetes. 

  • High blood sugar reduces inositol due to lower absorption, higher excretion, and impaired synthesis.

  • Supplementing may improve glucose metabolism, which is key for Hashimoto’s-related weight loss (BMJ Open Heart).

While the Western diet typically provides around 1 gram of inositol daily, absorption can be compromised by factors like gut dysbiosis, medications, and caffeine. The body also makes its own inositol, up to 4 grams per day in the kidneys, but this process may be impaired in certain health conditions. Although inositol is present in foods like walnuts, Brazil nuts, beans, peas, cantaloupe, almonds, and citrus fruits, ancestral diets were naturally richer in it due to the consumption of organ meats, such as kidneys and brain, which are no longer common in modern meals. 

Because of this, many people, especially those with Hashimoto’s, may benefit from targeted inositol supplementation.

A quick note from me to you

Because inositol is so powerful in supporting TSH and blood sugar, it’s possible that some may actually need less thyroid medication or blood sugar support (if you are on diabetes medication) over time. 

Everyone is different, of course, but I’ve seen this happen enough that I always recommend keeping an eye on things. For this reason, please monitor your thyroid labs and check your blood sugar regularly while taking ThyroLove, especially if you’re already on medication and work closely with your provider to assess those results to monitor your medication needs.

When checking thyroid labs, I always recommend a full thyroid panel so that you can really assess how things are working. A full Thyroid Panel includes: TSH, Total T4, Total T3, Free T4, Free T3, Reverse T3, T3 Uptake and Thyroid Antibodies (Thyroid Peroxidase Antibodies-TPO and Thyroglobulin Antibodies-TG)